From Impossible to Measurable
— The Brightest Bio Story
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Plasmonic Fluor – an ultrabright
nanoconstruct that is over 10,000 times
brighter than any molecular fluor
Plasmonic Fluor – an ultrabright
nanoconstruct that is over
10,000 times brighter than any
molecular fluor
Conventional Fluorescence
Plasmon-Enhanced Fluorescence
Familiar Workflow
Functionalized to enable a familiar ELISA-like workflow
ELISA
PFLISA
Capture
Antibody
Biotinylated
Antibody
Streptavidin HRP
Analyte
Streptavidin PF
Ultrahigh Performance
›100X improvement in assay sensitivity compared to equivalent ELISA with significantly increased dynamic range ›100X improvement in assay sensitivity compared to equivalent ELISA with significantly increased dynamic range
Publications
SUN-044 Plasmonic Fluor Provides Ultrasensitive Detection of Kidney Injury Biomarkers on Antibody Sandwich Microarrays
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Kidney International Reports
2020
Ultrabright Fluorescent Nanoscale Labels for the Femtomolar Detection of Analytes with Standard Bioassays
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Nature Biomedical Engineering
2020
Microneedle Patch for the Ultrasensitive Quantification of Protein Biomarkers in Interstitial Fluid
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Nature Biomedical Engineering
2021
Gold Nanorod Size-Dependent Fluorescence Enhancement for Ultrasensitive Fluoroimmunoassays
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ACS Applied Materials & Interfaces
2021
Plasmonically Enhanced CRISPR/Cas13a-Based Bioassay for Amplification-Free Detection of Cancer-Associated RNA
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Advanced Healthcare Materials
2021
Ultrabright Plasmonic Fluor Nanolabel-Enabled Detection of a Urinary ER Stress Biomarker in Autosomal Dominant Tubulointerstitial Kidney Disease
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American Journal of Physiology
2021
Plasmonically Enhanced Ultrasensitive Epitope-Specific Serologic Assay for COVID-19
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Analytical Chemistry
2021
Plasmonically-Enhanced Competitive Assay for Ultrasensitive and Multiplexed Detection of Small Molecules
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Biosensors and Bioelectronics
2022
High-Resolution Imaging of Protein Secretion at the Single-Cell Level Using Plasmon-Enhanced FluoroDOT Assay
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Cell Reports Methods
2022
Ultrasensitive Lateral-Flow Assays via Plasmonically Active Antibody-Conjugated Fluorescent Nanoparticles
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Nature Biomedical Engineering
2023
Plasmon-Enhanced Expansion Microscopy
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Nano Letters
2023